Moving back to I Spy for this one and a nice sequence from the episode entitled Chrysanthemum. What we have is a view of the side door to the hotel which opens onto Nathan Road (for those who don't know, the main door of the hotel faces south towards Salisbury Rd and the harbour).
A second after the man in the hat follows Culp and Cosby, the camera pans across Nathan Road to the opposite side and we get a quick glimpse of another hotel that has since departed: The Ambassador.
The Ambassador was quite striking courtesy of a large mural on the Nathan Road-facing wall. Gwulo.com has a good closeup here: http://gwulo.com/node/14902. Although I'm unsure when it disappeared - probably when Oterprise Square replaced it (whenever that was, it's build date seems to be eluding me at the moment) - it was built in 1960 and so was only a few years old as we see it above.
Eagle-eyed readers may also have noticed the rather large space standing on the south side of Middle Road (on the other side of the bus in the pic above). This of course is now the Sheraton Hotel, but in 1965 was just a large open car park. The hotel didn't appear until 1973.